High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses

High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout...

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Main Authors: Mudhasani, Rajini, Kota, Krishna P., Retterer, Cary, Tran, Julie P., Whitehouse, Chris A., Bavari, Sina
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140764/
https://ncbi.nlm.nih.gov/pubmed/25144302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003095
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