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Detection of MPLW515L/K Mutations and Determination of Allele Frequencies with a Single-Tube PCR Assay

A gain-of-function mutation in the myeloproliferative leukemia virus (MPL) gene, which encodes the thrombopoietin receptor, has been identified in patients with essential thrombocythemia and primary myelofibrosis, subgroups of classic myeloproliferative neoplasms (MPNs). The presence of MPL gene mut...

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Detalhes bibliográficos
Main Authors: Takei, Hiraku, Morishita, Soji, Araki, Marito, Edahiro, Yoko, Sunami, Yoshitaka, Hironaka, Yumi, Noda, Naohiro, Sekiguchi, Yuji, Tsuneda, Satoshi, Ohsaka, Akimichi, Komatsu, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140728/
https://ncbi.nlm.nih.gov/pubmed/25144224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104958
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