Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

The PI3K/Akt pathway plays a crucial role in the pathogenesis of multiple myeloma (MM) in the bone marrow (BM) milieu. However, efficacy of selective and potent Akt inhibition has not yet been fully elucidated. In this study, we therefore examined the biologic impact of selective and potent Akt inhi...

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Main Authors: Mimura, Naoya, Hideshima, Teru, Shimomura, Toshiyasu, Suzuki, Rikio, Ohguchi, Hiroto, Rizq, Ola, Kikuchi, Shohei, Yoshida, Yasuhiro, Cottini, Francesca, Jakubikova, Jana, Cirstea, Diana, Gorgun, Gullu, Minami, Jiro, Tai, Yu-Tzu, Richardson, Paul G., Utsugi, Teruhiro, Iwama, Atsushi, Anderson, Kenneth C.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140659/
https://ncbi.nlm.nih.gov/pubmed/24934808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3652
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