High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection

[Image: see text] Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative disorders and is a target for development of both diagnostic tools and therapeutic strategies across the tauopathy disease spectrum. Development of carbon-11- or fluorine-18-labeled radiotracers with...

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Autors principals: Fawaz, Maria V., Brooks, Allen F., Rodnick, Melissa E., Carpenter, Garrett M., Shao, Xia, Desmond, Timothy J., Sherman, Phillip, Quesada, Carole A., Hockley, Brian G., Kilbourn, Michael R., Albin, Roger L., Frey, Kirk A., Scott, Peter J. H.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140593/
https://ncbi.nlm.nih.gov/pubmed/24896980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500103u
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