High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection

[Image: see text] Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative disorders and is a target for development of both diagnostic tools and therapeutic strategies across the tauopathy disease spectrum. Development of carbon-11- or fluorine-18-labeled radiotracers with...

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Detalhes bibliográficos
Main Authors: Fawaz, Maria V., Brooks, Allen F., Rodnick, Melissa E., Carpenter, Garrett M., Shao, Xia, Desmond, Timothy J., Sherman, Phillip, Quesada, Carole A., Hockley, Brian G., Kilbourn, Michael R., Albin, Roger L., Frey, Kirk A., Scott, Peter J. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140593/
https://ncbi.nlm.nih.gov/pubmed/24896980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500103u
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