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Molecular Umbrella–Amphotericin B Conjugates

[Image: see text] A tetrawalled and an octawalled molecular umbrella conjugate of amphotericin B (AmB) have been synthesized. Both conjugates exhibit high water solubility, a low tendency to aggregate, negligible hemolytic activity at 100 μM, and an ability to release a derivative of AmB under reduc...

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Detalhes bibliográficos
Main Authors: Janout, Vaclav, Bienvenu, Celine, Schell, Wiley, Perfect, John R., Regen, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140546/
https://ncbi.nlm.nih.gov/pubmed/25068916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500277v
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