Extracellular UDP-Glucose Activates P2Y(14) Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr(705) Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

Hyaluronan, a major matrix molecule in epidermis, is often increased by stimuli that enhance keratinocyte proliferation and migration. We found that small amounts of UDP-sugars were released from keratinocytes and that UDP-glucose (UDP-Glc) added into keratinocyte cultures induced a specific, rapid...

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Bibliographic Details
Main Authors: Jokela, Tiina A., Kärnä, Riikka, Makkonen, Katri M., Laitinen, Jarmo T., Tammi, Raija H., Tammi, Markku I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140273/
https://ncbi.nlm.nih.gov/pubmed/24847057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551804
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