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Extracellular UDP-Glucose Activates P2Y(14) Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr(705) Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes
Hyaluronan, a major matrix molecule in epidermis, is often increased by stimuli that enhance keratinocyte proliferation and migration. We found that small amounts of UDP-sugars were released from keratinocytes and that UDP-glucose (UDP-Glc) added into keratinocyte cultures induced a specific, rapid...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140273/ https://ncbi.nlm.nih.gov/pubmed/24847057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551804 |
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