Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Down-regulation of Hyaluronan Synthase 2 through Inhibition of Akt

Hyaluronan synthases (HAS1–3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes. It has been shown that HAS is partly localized in cholesterol-rich lipid rafts of MCF-7 cells, and cholester...

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Main Authors: Kultti, Anne, Kärnä, Riikka, Rilla, Kirsi, Nurminen, Pertti, Koli, Elina, Makkonen, Katri M., Si, Jutong, Tammi, Markku I., Tammi, Raija H.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Glycobiology and Extracellular Matrices
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906282/
https://ncbi.nlm.nih.gov/pubmed/20501660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088435
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