Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1

Hyaluronan, a high molecular mass polysaccharide on the vertebrate cell surface and extracellular matrix, is produced at the plasma membrane by hyaluronan synthases using UDP-GlcNAc and UDP-GlcUA as substrates. The availability of these UDP-sugar substrates can limit the synthesis rate of hyaluronan...

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Autors principals: Jokela, Tiina A., Makkonen, Katri M., Oikari, Sanna, Kärnä, Riikka, Koli, Elina, Hart, Gerald W., Tammi, Raija H., Carlberg, Carsten, Tammi, Markku I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190925/
https://ncbi.nlm.nih.gov/pubmed/21795679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265637
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