The Notch pathway controls fibrotic and regenerative repair in the adult heart

AIMS: In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stromal cell fraction, which contains cardiac fibroblast...

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Bibliographic Details
Main Authors: Nemir, Mohamed, Metrich, Mélanie, Plaisance, Isabelle, Lepore, Mario, Cruchet, Steeve, Berthonneche, Corinne, Sarre, Alexandre, Radtke, Freddy, Pedrazzini, Thierry
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Basic Science
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139705/
https://ncbi.nlm.nih.gov/pubmed/23166366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehs269
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