Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation

Alternative (M2) macrophage activation driven through interleukin 4 receptor α (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of atherosclerosis and metabolic homeostasis. M2 polarization is dependent on fatty acid oxidation (FAO), but the source of fatty acids to sup...

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Main Authors: Huang, Stanley Ching-Cheng, Everts, Bart, Ivanova, Yulia, O'Sullivan, David, Nascimento, Marcia, Smith, Amber M., Beatty, Wandy, Love-Gregory, Latisha, Lam, Wing Y., O'Neill, Christina M., Yan, Cong, Du, Hong, Abumrad, Nada A., Urban, Joseph F., Artyomov, Maxim N., Pearce, Erika L., Pearce, Edward J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139419/
https://ncbi.nlm.nih.gov/pubmed/25086775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2956
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