Memory CD8(+) T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development

Generation of CD8(+) memory T (T(M)) cells requires metabolic reprogramming that is characterized by enhanced mitochondrial fatty acid oxidation (FAO). However, where the fatty acids (FA) that fuel this process come from remains unclear. We found that while CD8(+) T(M) cells engaged higher levels of...

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Main Authors: O’Sullivan, David, van der Windt, Gerritje J. W., Ching-Cheng Huang, Stanley, Curtis, Jonathan D., Chang, Chih-Hao, Buck, Michael D., Qiu, Jing, Smith, Amber M., Lam, Wing Y., DiPlato, Lisa M., Hsu, Fong-Fu, Birnbaum, Morris J., Pearce, Edward J., Pearce, Erika L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120664/
https://ncbi.nlm.nih.gov/pubmed/25001241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.005
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