Memory CD8(+) T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development

Generation of CD8(+) memory T (T(M)) cells requires metabolic reprogramming that is characterized by enhanced mitochondrial fatty acid oxidation (FAO). However, where the fatty acids (FA) that fuel this process come from remains unclear. We found that while CD8(+) T(M) cells engaged higher levels of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: O’Sullivan, David, van der Windt, Gerritje J. W., Ching-Cheng Huang, Stanley, Curtis, Jonathan D., Chang, Chih-Hao, Buck, Michael D., Qiu, Jing, Smith, Amber M., Lam, Wing Y., DiPlato, Lisa M., Hsu, Fong-Fu, Birnbaum, Morris J., Pearce, Edward J., Pearce, Erika L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120664/
https://ncbi.nlm.nih.gov/pubmed/25001241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.005
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge