4-1BBL Enhances CD8(+) T Cell Responses Induced by Vectored Vaccines in Mice but Fails to Improve Immunogenicity in Rhesus Macaques

T cells play a central role in the immune response to many of the world’s major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a variety o...

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Bibliographic Details
Main Authors: Spencer, Alexandra J., Furze, Julie, Honeycutt, Jared D., Calvert, Alice, Saurya, Saroj, Colloca, Stefano, Wyllie, David H., Gilbert, Sarah C., Bregu, Migena, Cottingham, Matthew G., Hill, Adrian V. S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139357/
https://ncbi.nlm.nih.gov/pubmed/25140889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105520
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