Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates

To prevent important infectious diseases such as tuberculosis, malaria and HIV, vaccines inducing greater T cell responses are required. In this study, we investigated whether fusion of the M. tuberculosis antigen 85A to recently described adjuvant IMX313, a hybrid avian C4bp oligomerization domain,...

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Detalhes bibliográficos
Main Authors: Spencer, Alexandra J., Hill, Fergal, Honeycutt, Jared D., Cottingham, Matthew G., Bregu, Migena, Rollier, Christine S., Furze, Julie, Draper, Simon J., Søgaard, Karen C., Gilbert, Sarah C., Wyllie, David H., Hill, Adrian V. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314664/
https://ncbi.nlm.nih.gov/pubmed/22470455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033555
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