Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells

Abundant, sustained expression of prosurvival Mcl-1 is an important determinant of viability and drug resistance in cancer cells. The Mcl-1 protein contains PEST sequences (enriched in proline, glutamic acid, serine, and threonine) and is normally subject to rapid turnover via multiple different pat...

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Hlavní autoři: Nifoussi, Shanna K., Ratcliffe, Nora R., Ornstein, Deborah L., Kasof, Gary, Strack, Stefan, Craig, Ruth W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139212/
https://ncbi.nlm.nih.gov/pubmed/24939844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587873
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