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Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling
The Ca(2+) sensor for rapid synaptic vesicle exocytosis, synaptotagmin I (syt), is largely composed of two Ca(2+)-sensing C2-domains, C2A and C2B. We have investigated the apparent synergy between the tandem C2 domains by altering the length and rigidity of the linker that connects them. The behavio...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139111/ https://ncbi.nlm.nih.gov/pubmed/24657966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3681 |
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