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Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy

Synaptotagmin I is the major Ca(2+) sensor for membrane fusion during neurotransmitter release. The cytoplasmic domain of synaptotagmin consists of two C2 domains, C2A and C2B. On binding Ca(2+), the tips of the two C2 domains rapidly and synchronously penetrate lipid bilayers. We investigated the f...

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Autori principali: Takahashi, Hirohide, Shahin, Victor, Henderson, Robert M., Takeyasu, Kunio, Edwardson, J. Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956219/
https://ncbi.nlm.nih.gov/pubmed/20959096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.047
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