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Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy
Synaptotagmin I is the major Ca(2+) sensor for membrane fusion during neurotransmitter release. The cytoplasmic domain of synaptotagmin consists of two C2 domains, C2A and C2B. On binding Ca(2+), the tips of the two C2 domains rapidly and synchronously penetrate lipid bilayers. We investigated the f...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956219/ https://ncbi.nlm.nih.gov/pubmed/20959096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.047 |
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