Affinity-Matured Recombinant Antibody Fragments Analyzed by Single-Molecule Force Spectroscopy

For many applications, antibodies need to be engineered toward maximum affinity. Strategies are in demand to especially optimize this process toward slower dissociation rates, which correlate with the (un)binding forces. Using single-molecule force spectroscopy, we have characterized three variants...

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Bibliografske podrobnosti
Main Authors: Morfill, Julia, Blank, Kerstin, Zahnd, Christian, Luginbühl, Beatrice, Kühner, Ferdinand, Gottschalk, Kay-E., Plückthun, Andreas, Gaub, Hermann E.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2007
Teme:
Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072072/
https://ncbi.nlm.nih.gov/pubmed/17675348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112532
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