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Affinity-Matured Recombinant Antibody Fragments Analyzed by Single-Molecule Force Spectroscopy
For many applications, antibodies need to be engineered toward maximum affinity. Strategies are in demand to especially optimize this process toward slower dissociation rates, which correlate with the (un)binding forces. Using single-molecule force spectroscopy, we have characterized three variants...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Biophysical Society
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2072072/ https://ncbi.nlm.nih.gov/pubmed/17675348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112532 |
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