Affinity-Matured Recombinant Antibody Fragments Analyzed by Single-Molecule Force Spectroscopy

For many applications, antibodies need to be engineered toward maximum affinity. Strategies are in demand to especially optimize this process toward slower dissociation rates, which correlate with the (un)binding forces. Using single-molecule force spectroscopy, we have characterized three variants...

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Dettagli Bibliografici
Autori principali: Morfill, Julia, Blank, Kerstin, Zahnd, Christian, Luginbühl, Beatrice, Kühner, Ferdinand, Gottschalk, Kay-E., Plückthun, Andreas, Gaub, Hermann E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2007
Soggetti:
Proteins
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072072/
https://ncbi.nlm.nih.gov/pubmed/17675348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112532
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