Computational design of self-assembling protein nanomaterials with atomic level accuracy

We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the...

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Bibliographic Details
Main Authors: King, Neil P., Sheffler, William, Sawaya, Michael R., Vollmar, Breanna S., Sumida, John P., André, Ingemar, Gonen, Tamir, Yeates, Todd O., Baker, David
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138882/
https://ncbi.nlm.nih.gov/pubmed/22654060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219364
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