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Rab5 Activity Regulates GLUT4 Sorting Into Insulin-Responsive and Non-Insulin-Responsive Endosomal Compartments: A Potential Mechanism for Development of Insulin Resistance

Glucose transporter isoform 4 (GLUT4) is the insulin-responsive glucose transporter mediating glucose uptake in adipose and skeletal muscle. Reduced GLUT4 translocation from intracellular storage compartments to the plasma membrane is a cause of peripheral insulin resistance. Using a chronic hyperin...

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Detalhes bibliográficos
Main Authors: Tessneer, Kandice L., Jackson, Robert M., Griesel, Beth A., Olson, Ann Louise
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138579/
https://ncbi.nlm.nih.gov/pubmed/24932807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2148
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