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A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin. A critical challenge for translating this therapeutic network...

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Bibliografiske detaljer
Main Authors: Morton, Stephen W., Lee, Michael J., Deng, Zhou J., Dreaden, Erik C., Siouve, Elise, Shopsowitz, Kevin E., Shah, Nisarg J., Yaffe, Michael B., Hammond, Paula T.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138219/
https://ncbi.nlm.nih.gov/pubmed/24825919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005261
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