Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle

PURPOSE: Cross-talk and feedback between the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR cell signaling pathways is critical for tumor initiation, maintenance, and adaptive resistance to targeted therapy in a variety of solid tumors. Combined blockade of these pathways—horizontal blockade—is a promising thera...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Dreaden, Erik C., Kong, Yi Wen, Morton, Stephen W., Correa, Santiago, Choi, Ki Young, Shopsowitz, Kevin E., Renggli, Kasper, Drapkin, Ronny, Yaffe, Michael B., Hammond, Paula T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624301/
https://ncbi.nlm.nih.gov/pubmed/26034127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0013
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