Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1

[Image: see text] The flavone backbone is a well-known pharmacophore present in a number of substrates and inhibitors of various P450 enzymes. In order to find highly potent and novel P450 family I enzyme inhibitors, an acetylene group was incorporated into six different positions of flavone. The in...

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Główni autorzy: Goyal, Navneet, Liu, Jiawang, Lovings, La’Nese, Dupart, Patrick, Taylor, Shannon, Bellow, Sydni, Mensah, Lydia, McClain, Erika, Dotson, Brandan, Sridhar, Jayalakshmi, Zhang, Xiaoyi, Zhao, Ming, Foroozesh, Maryam
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2014
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137986/
https://ncbi.nlm.nih.gov/pubmed/25033111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5001865
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