Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.

Lysosomal enzymes containing mannose 6-phosphate recognition markers are sorted to lysosomes by mannose 6-phosphate receptors (MPRs). The physiological importance of this targeting mechanism is illustrated by I-cell disease, a fatal lysosomal storage disorder caused by the absence of mannose 6-phosp...

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Detalhes bibliográficos
Publicado no:EMBO J
Principais autores: Köster, A, Saftig, P, Matzner, U, von Figura, K, Peters, C, Pohlmann, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413786/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8262064/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06217.x
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