Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.

Lysosomal enzymes containing mannose 6-phosphate recognition markers are sorted to lysosomes by mannose 6-phosphate receptors (MPRs). The physiological importance of this targeting mechanism is illustrated by I-cell disease, a fatal lysosomal storage disorder caused by the absence of mannose 6-phosp...

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Argitaratua izan da:	EMBO J
Egile Nagusiak:	Köster, A, Saftig, P, Matzner, U, von Figura, K, Peters, C, Pohlmann, R
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 1993
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8262064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06217.x
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