Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells

[Image: see text] Mutations in the lysosomal enzyme, N-sulfoglucosamine sulfohydrolase (SGSH), also called sulfamidase, cause accumulation of lysosomal inclusion bodies in the brain of children born with mucopolysaccharidosis type IIIA, also called Sanfilippo type A syndrome. Enzyme replacement ther...

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Bibliografiske detaljer
Main Authors: Boado, Ruben J., Lu, Jeff Zhiqiang, Hui, Eric Ka-Wai, Pardridge, William M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137762/
https://ncbi.nlm.nih.gov/pubmed/24949884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500258p
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