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Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.
OBJECTIVE: Mild decrease in core temperature (therapeutic hypothermia; TH) provides lasting neuroprotection following cardiac arrest or cerebral ischemia. However, current methods for producing TH trigger a cold-defense response which must be countered by sedatives, muscle paralytics and mechanical...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137592/ https://ncbi.nlm.nih.gov/pubmed/24595220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000229 |
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