Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.

OBJECTIVE: Mild decrease in core temperature (therapeutic hypothermia; TH) provides lasting neuroprotection following cardiac arrest or cerebral ischemia. However, current methods for producing TH trigger a cold-defense response which must be countered by sedatives, muscle paralytics and mechanical...

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Main Authors: Feketa, Viktor V., Zhang, Yi, Cao, Zhijuan, Balasubramanian, Adithya, Flores, Christopher M., Player, Mark R., Marrelli, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137592/
https://ncbi.nlm.nih.gov/pubmed/24595220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000229
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