dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.

dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the incorporation of uracil into DNA during replication. Although it is widely believed that dUTPase is essential for cell viability because of this role, direct evidence supporting this...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	Gadsden, M H, McIntosh, E M, Game, J C, Wilson, P J, Haynes, R H
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8223452/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06127.x
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