Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol

[Image: see text] In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacological properties revealed. We herei...

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Autors principals: Schunk, Stefan, Linz, Klaus, Hinze, Claudia, Frormann, Sven, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y., Schröder, Wolfgang, Harlfinger, Stephanie, Saunders, Derek, Kless, Achim, Schick, Hans, Sonnenschein, Helmut
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137374/
https://ncbi.nlm.nih.gov/pubmed/25147603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500117c
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