Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists

[Image: see text] We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethylamino)-4-phenylcyclo-hexanone 1 a...

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Main Authors: Schunk, Stefan, Linz, Klaus, Frormann, Sven, Hinze, Claudia, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y., Schröder, Wolfgang, Harlfinger, Stephanie, Saunders, Derek, Kless, Achim, Schick, Hans, Sonnenschein, Helmut
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137372/
https://ncbi.nlm.nih.gov/pubmed/25147602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500116x
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