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Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter

[Image: see text] TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. The light- and air-sensitivity prevented in-depth exploitation of this novel indole derivative. Herein, we report the first synthesis of TMC-205. On the basis of its reactivity with re...

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Détails bibliographiques
Auteurs principaux: Gao, Yang, Osman, Sami, Koide, Kazunori
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137371/
https://ncbi.nlm.nih.gov/pubmed/25147604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500025p
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