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Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter
[Image: see text] TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. The light- and air-sensitivity prevented in-depth exploitation of this novel indole derivative. Herein, we report the first synthesis of TMC-205. On the basis of its reactivity with re...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137371/ https://ncbi.nlm.nih.gov/pubmed/25147604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500025p |
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