Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling

Pulmonary artery smooth muscle cell (PASMC) proliferation plays a fundamental role in the vascular remodeling seen in pulmonary hypertensive diseases associated with hypoxia. Arginase II, an enzyme regulating the first step in polyamine and proline synthesis, has been shown to play a critical role i...

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Hlavní autoři: Chen, Bernadette, Xue, Jianjing, Meng, Xiaomei, Slutzky, Jessica L., Calvert, Andrea E., Chicoine, Louis G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137162/
https://ncbi.nlm.nih.gov/pubmed/24951775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00285.2013
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