Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

The mitogen-activated protein (MAP) kinases are involved in cellular responses to many stimuli, including hypoxia. MAP kinase signaling is regulated by a family of phosphatases that include MAP kinase phosphatase-1 (MKP-1). We hypothesized that mice lacking the Mkp-1 gene would have exaggerated chro...

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Detalhes bibliográficos
Main Authors: Jin, Yi, Calvert, Thomas J., Chen, Bernadette, Chicoine, Louis G., Joshi, Mandar, Bauer, John Anthony, Liu, Yusen, Nelin, Leif D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867445/
https://ncbi.nlm.nih.gov/pubmed/20173047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00813.2009
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