Hydrocortisone Fails to Abolish NF-κB1 Protein Nuclear Translocation in Deletion Allele Carriers of the NFKB1 Promoter Polymorphism (-94ins/delATTG) and Is Associated with Increased 30-Day Mortality in Septic Shock

BACKGROUND: Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG) of the gene encoding the ubiquitous transcr...

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Hauptverfasser: Schäfer, Simon T., Gessner, Sophia, Scherag, André, Rump, Katharina, Frey, Ulrich H., Siffert, Winfried, Westendorf, Astrid M., Steinmann, Jörg, Peters, Jürgen, Adamzik, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136840/
https://ncbi.nlm.nih.gov/pubmed/25133403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104953
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