Mechanistic Insight with HBCH(2)CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases

[Image: see text] Polyhydroxybutyrate (PHB) synthases catalyze the polymerization of 3-(R)-hydroxybutyrate coenzyme A (HBCoA) to produce polyoxoesters of 1–2 MDa. A substrate analogue HBCH(2)CoA, in which the S in HBCoA is replaced with a CH(2) group, was synthesized in 13 steps using a chemoenzymat...

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Main Authors: Zhang, Wei, Shrestha, Ruben, Buckley, Rachael M., Jewell, Jamie, Bossmann, Stefan H., Stubbe, JoAnne, Li, Ping
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136709/
https://ncbi.nlm.nih.gov/pubmed/24896226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5002735
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