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Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks
BRCA2 is a tumor suppressor that maintains genomic integrity through double strand break (DSB) repair and replication fork protection. The BRC motifs and an exon 27-encoded domain (Ex27) of BRCA2 interact with the recombinase RAD51 to respectively facilitate the formation and stability of a RAD51 fi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136705/ https://ncbi.nlm.nih.gov/pubmed/25773776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2014.06.003 |
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