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Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks

BRCA2 is a tumor suppressor that maintains genomic integrity through double strand break (DSB) repair and replication fork protection. The BRC motifs and an exon 27-encoded domain (Ex27) of BRCA2 interact with the recombinase RAD51 to respectively facilitate the formation and stability of a RAD51 fi...

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Detalhes bibliográficos
Main Authors: Kim, Tae Moon, Son, Mi Young, Dodds, Sherry, Hu, Lingchuan, Hasty, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136705/
https://ncbi.nlm.nih.gov/pubmed/25773776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2014.06.003
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