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Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell differentiatio...

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Hlavní autoři: Tsagaratou, Ageliki, Äijö, Tarmo, Lio, Chan-Wang J., Yue, Xiaojing, Huang, Yun, Jacobsen, Steven E., Lähdesmäki, Harri, Rao, Anjana
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136618/
https://ncbi.nlm.nih.gov/pubmed/25071199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412327111
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