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Histone Deacetylase Inhibitor Sensitizes Apoptosis-resistant Melanomas to Cytotoxic Human T Lymphocytes through Regulation of TRAIL/DR5 Pathway
Modern immune therapies [PD-1/PD-L1 and CTLA-4 checkpoints blockade, and adoptive cell transfer (ACT)] have remarkably improved the response rates of metastatic melanoma. These modalities rely on the killing potential of cytotoxic T lymphocytes (CTL) as proximal mediator of anti-melanoma responses....
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136528/ https://ncbi.nlm.nih.gov/pubmed/24639349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302532 |
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