IL-23 Promotes TCR-mediated Negative Selection of Thymocytes through the Upregulation of IL-23 Receptor and RORγt

Transient thymic involution is frequently found during inflammation, yet the mode of action of inflammatory cytokines is not well defined. Here we report that interleukin-23 (IL-23) production by the thymic dendritic cells (DCs) promotes apoptosis of the CD4(hi)CD8(hi) double positive (DP) thymocyte...

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Detalhes bibliográficos
Main Authors: Li, Hao, Hsu, Hui-Chen, Wu, Qi, Yang, PingAr, Li, Jun, Luo, Bao, Oukka, Mohamed, Steele, Claude H., Cua, Daniel J, Grizzle, William E., Mountz, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136447/
https://ncbi.nlm.nih.gov/pubmed/25001511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5259
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