Characterization and Immunogenicity of a Novel Mosaic M HIV-1 gp140 Trimer

The extraordinary diversity of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein poses a major challenge for the development of an HIV-1 vaccine. One strategy to circumvent this problem utilizes bioinformatically optimized mosaic antigens. However, mosaic Env proteins expre...

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Hlavní autoři: Nkolola, Joseph P., Bricault, Christine A., Cheung, Ann, Shields, Jennifer, Perry, James, Kovacs, James M., Giorgi, Elena, van Winsen, Margot, Apetri, Adrian, Brinkman-van der Linden, Els C. M., Chen, Bing, Korber, Bette, Seaman, Michael S., Barouch, Dan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136343/
https://ncbi.nlm.nih.gov/pubmed/24965452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01739-14
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