A Multivalent Clade C HIV-1 Env Trimer Cocktail Elicits a Higher Magnitude of Neutralizing Antibodies than Any Individual Component

The sequence diversity of human immunodeficiency virus type 1 (HIV-1) presents a formidable challenge to the generation of an HIV-1 vaccine. One strategy to address such sequence diversity and to improve the magnitude of neutralizing antibodies (NAbs) is to utilize multivalent mixtures of HIV-1 enve...

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Vydáno v:J Virol
Hlavní autoři: Bricault, Christine A., Kovacs, James M., Nkolola, Joseph P., Yusim, Karina, Giorgi, Elena E., Shields, Jennifer L., Perry, James, Lavine, Christy L., Cheung, Ann, Ellingson-Strouss, Katharine, Rademeyer, Cecelia, Gray, Glenda E., Williamson, Carolyn, Stamatatos, Leonidas, Seaman, Michael S., Korber, Bette T., Chen, Bing, Barouch, Dan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325749/
https://ncbi.nlm.nih.gov/pubmed/25540368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03331-14
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