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Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon
NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C(pro)) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral inductio...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136334/ https://ncbi.nlm.nih.gov/pubmed/24920812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00869-14 |
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