Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon

NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3C(pro)) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral inductio...

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Bibliografische gegevens
Hoofdauteurs: Wang, Dang, Fang, Liurong, Wei, Dahai, Zhang, Huan, Luo, Rui, Chen, Huanchun, Li, Kui, Xiao, Shaobo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136334/
https://ncbi.nlm.nih.gov/pubmed/24920812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00869-14
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