Comprehensive Analysis of Contributions from Protein Conformational Stability and Major Histocompatibility Complex Class II-Peptide Binding Affinity to CD4(+) Epitope Immunogenicity in HIV-1 Envelope Glycoprotein

Helper T-cell epitope dominance in human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is not adequately explained by peptide binding to major histocompatibility complex (MHC) proteins. Antigen processing potentially influences epitope dominance, but few, if any, studies have att...

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Main Authors: Li, Tingfeng, Steede, N. Kalaya, Nguyen, Hong-Nam P., Freytag, Lucy C., McLachlan, James B., Mettu, Ramgopal R., Robinson, James E., Landry, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136326/
https://ncbi.nlm.nih.gov/pubmed/24920818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00789-14
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