High-Throughput Identification of Loss-of-Function Mutations for Anti-Interferon Activity in the Influenza A Virus NS Segment

Viral proteins often display several functions which require multiple assays to dissect their genetic basis. Here, we describe a systematic approach to screen for loss-of-function mutations that confer a fitness disadvantage under a specified growth condition. Our methodology was achieved by genetic...

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Hlavní autoři: Wu, Nicholas C., Young, Arthur P., Al-Mawsawi, Laith Q., Olson, C. Anders, Feng, Jun, Qi, Hangfei, Luan, Harding H., Li, Xinmin, Wu, Ting-Ting, Sun, Ren
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136320/
https://ncbi.nlm.nih.gov/pubmed/24965464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01494-14
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